Sadie has had ongoing rear leg issues. She has had TPLO surgery on her left leg and three surgeries on her right leg. The only thing they can contribute her problem to was a medication she was given as a puppy. We lived in Florida at the time and the vet gave her Baytril. All the vets and specialists we have seen her in VA immediately point to the Baytril. It should never be given to a large breed puppy while it is still in the growth stage. It causes problems with joint formation.